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colon cancer cell line rko  (ATCC)


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    ATCC colon cancer cell line rko
    Colon Cancer Cell Line Rko, supplied by ATCC, used in various techniques. Bioz Stars score: 97/100, based on 2008 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/colon cancer cell line rko/product/ATCC
    Average 97 stars, based on 2008 article reviews
    colon cancer cell line rko - by Bioz Stars, 2026-05
    97/100 stars

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    DIM-3,5 analogs inhibit cancer cell growth and modulate expression of NR4A1-regulated gene products. <t>RKO</t> ( A <t>),</t> <t>SW480</t> ( B ) and HCT116 ( C ) cells were treated with 2.5–20 µmol/L DIM-3,5-CI 2 , DIM-3-CI-5-CF 3 and DIM-3,5-Br 2 for 24 h and effects on cell proliferation were determined as outlined in . RKO and SW480 cells were treated with DIM-3,5 analogs for 24 h and whole-cell lysates were analyzed by Western blots (in triplicate), G9a, β1-integrin and apoptosis ( D , E ) and Sp/NR4A gene products ( F , G ). Results are expressed as means ± SE for at least 3 determinations for each treatment group and significant ( p < 0.05) inhibition/induction compared to DMSO (control) is indicated (*) ( A – C ); quantitative results for ( D – G ) are summarized in ( H , I ) within the figure.
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    DIM-3,5 analogs inhibit cancer cell growth and modulate expression of NR4A1-regulated gene products. RKO ( A ), SW480 ( B ) and HCT116 ( C ) cells were treated with 2.5–20 µmol/L DIM-3,5-CI 2 , DIM-3-CI-5-CF 3 and DIM-3,5-Br 2 for 24 h and effects on cell proliferation were determined as outlined in . RKO and SW480 cells were treated with DIM-3,5 analogs for 24 h and whole-cell lysates were analyzed by Western blots (in triplicate), G9a, β1-integrin and apoptosis ( D , E ) and Sp/NR4A gene products ( F , G ). Results are expressed as means ± SE for at least 3 determinations for each treatment group and significant ( p < 0.05) inhibition/induction compared to DMSO (control) is indicated (*) ( A – C ); quantitative results for ( D – G ) are summarized in ( H , I ) within the figure.

    Journal: International Journal of Molecular Sciences

    Article Title: Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands

    doi: 10.3390/ijms26083909

    Figure Lengend Snippet: DIM-3,5 analogs inhibit cancer cell growth and modulate expression of NR4A1-regulated gene products. RKO ( A ), SW480 ( B ) and HCT116 ( C ) cells were treated with 2.5–20 µmol/L DIM-3,5-CI 2 , DIM-3-CI-5-CF 3 and DIM-3,5-Br 2 for 24 h and effects on cell proliferation were determined as outlined in . RKO and SW480 cells were treated with DIM-3,5 analogs for 24 h and whole-cell lysates were analyzed by Western blots (in triplicate), G9a, β1-integrin and apoptosis ( D , E ) and Sp/NR4A gene products ( F , G ). Results are expressed as means ± SE for at least 3 determinations for each treatment group and significant ( p < 0.05) inhibition/induction compared to DMSO (control) is indicated (*) ( A – C ); quantitative results for ( D – G ) are summarized in ( H , I ) within the figure.

    Article Snippet: Three colon cancer cell lines RKO (RRID:CVCL_0504), SW480 (RRID:CVCL_0546) and HCT116 (RRID:CVCL_0291) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: Expressing, Western Blot, Inhibition, Control

    NR4A1 and NR4A2 knockdown on colon cancer cell growth and expression of selected genes. RKO, SW480 and HCT116 cells were transfected with oligonucleotides targeting NR4A1 (siNR4A1) and NR4A2 (siNR4A2) ( A – C ) and cell viability was determined. Multiple oligonucleotides targeting NR4A1 and NR4A2 and their combination were transfected into RKO or SW480 cells and whole-cell lysates were analyzed by Western blots knockdown to determine efficiency ( D ) and effects on selected gene products ( E ) as outlined in . Significant ( p < 0.05) inhibition is indicated (*) in ( A – C ).

    Journal: International Journal of Molecular Sciences

    Article Title: Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands

    doi: 10.3390/ijms26083909

    Figure Lengend Snippet: NR4A1 and NR4A2 knockdown on colon cancer cell growth and expression of selected genes. RKO, SW480 and HCT116 cells were transfected with oligonucleotides targeting NR4A1 (siNR4A1) and NR4A2 (siNR4A2) ( A – C ) and cell viability was determined. Multiple oligonucleotides targeting NR4A1 and NR4A2 and their combination were transfected into RKO or SW480 cells and whole-cell lysates were analyzed by Western blots knockdown to determine efficiency ( D ) and effects on selected gene products ( E ) as outlined in . Significant ( p < 0.05) inhibition is indicated (*) in ( A – C ).

    Article Snippet: Three colon cancer cell lines RKO (RRID:CVCL_0504), SW480 (RRID:CVCL_0546) and HCT116 (RRID:CVCL_0291) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: Knockdown, Expressing, Transfection, Western Blot, Inhibition

    Effects of DIM-3,5 analogs on receptor-dependent transactivation. RKO ( A ), SW480 ( B ) and HCT116 ( C ) cells were transfected with GAL4-NR4A1 or GAL4-NR4A2 and a UAS-luc reporter gene and treated with DIM-3,5 analogs and luciferase activity was determined as outlined in . Results are expressed as means ± SE for at least 3 replicate determinations per treatment group, and significant ( p < 0.05) induction/inhibition is indicated (*).

    Journal: International Journal of Molecular Sciences

    Article Title: Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands

    doi: 10.3390/ijms26083909

    Figure Lengend Snippet: Effects of DIM-3,5 analogs on receptor-dependent transactivation. RKO ( A ), SW480 ( B ) and HCT116 ( C ) cells were transfected with GAL4-NR4A1 or GAL4-NR4A2 and a UAS-luc reporter gene and treated with DIM-3,5 analogs and luciferase activity was determined as outlined in . Results are expressed as means ± SE for at least 3 replicate determinations per treatment group, and significant ( p < 0.05) induction/inhibition is indicated (*).

    Article Snippet: Three colon cancer cell lines RKO (RRID:CVCL_0504), SW480 (RRID:CVCL_0546) and HCT116 (RRID:CVCL_0291) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: Transfection, Luciferase, Activity Assay, Inhibition

    Effects of Sp1/Sp4 downregulation and the ChIP assay on the G9a and β1-integrin promoters in ( A ). ( A ) RKO and SW480 cells were transfected with oligonucleotides targeting Sp1 (siSp1) or Sp4 (siSp4) and whole-cell lysates were analyzed by Western blots as outlined in . RKO cells were treated with DIM-3,5-CI 2 for 24 h and a ChIP assay was determined using primers for the β1-integrin ( B , C ) and G9a ( D , E ) promoters and interactions of NR4A1, NR4A2, Sp1 and Sp4 with the gene promoters was determined as outlined in the . Results ( B , D ) are means ± SE from 3 replicate experiments, and significantly ( p < 0.05) decreased mRNA levels are indicated (*).

    Journal: International Journal of Molecular Sciences

    Article Title: Expression of Prooncogenic Nuclear Receptor 4A (NR4A)-Regulated Genes β1-Integrin and G9a Inhibited by Dual NR4A1/2 Ligands

    doi: 10.3390/ijms26083909

    Figure Lengend Snippet: Effects of Sp1/Sp4 downregulation and the ChIP assay on the G9a and β1-integrin promoters in ( A ). ( A ) RKO and SW480 cells were transfected with oligonucleotides targeting Sp1 (siSp1) or Sp4 (siSp4) and whole-cell lysates were analyzed by Western blots as outlined in . RKO cells were treated with DIM-3,5-CI 2 for 24 h and a ChIP assay was determined using primers for the β1-integrin ( B , C ) and G9a ( D , E ) promoters and interactions of NR4A1, NR4A2, Sp1 and Sp4 with the gene promoters was determined as outlined in the . Results ( B , D ) are means ± SE from 3 replicate experiments, and significantly ( p < 0.05) decreased mRNA levels are indicated (*).

    Article Snippet: Three colon cancer cell lines RKO (RRID:CVCL_0504), SW480 (RRID:CVCL_0546) and HCT116 (RRID:CVCL_0291) were purchased from American Type Culture Collection (Manassas, VA, USA).

    Techniques: Transfection, Western Blot